Gymnema Extract | 90045-47-9

Product Description:

Gymnema sylvestre extract is extracted from the dried stems and leaves of Gymnema sylvestre plants. Gymnema sylvestre, also known as Gymnema sylvestris, is distributed in India, Vietnam, Indonesia, Australia, tropical Africa, and my country's Guangdong, Guangxi, Yunnan, Fujian, Zhejiang and Taiwan. The extract is mainly composed of total triterpenoid saponins, flavonoid glycosides, anthocyanins, polysaccharides and other components.

Total saponins is the active ingredient of Chemicalbook, which is composed of a variety of saponins, the most abundant of which is gymnematic acid.

Gymnema sylvestre extract has the effects of expelling wind and cooling blood, reducing swelling and pain, strengthening stomach and diuresis, and is used for wind-cold-damp arthralgia, diabetes, vasculitis, etc. In recent years, scholars at home and abroad have found that it has the functions of lowering blood sugar, lowering blood lipids, anti-atherosclerosis, inhibiting sweetness, anti-dental caries and inhibiting obesity, and has broad application prospects in the fields of medicines, functional foods and health care products.

The efficacy and role of Gymnema Extract： 

Hypoglycemic effect:

Gymnema sylvestre extract can slightly increase normal blood sugar, but when combined with glucose or sucrose, it can significantly inhibit the increase of blood sugar level and significantly reduce the secretion of plasma insulin.

Hypolipidemic and anti-atherosclerotic effects:

Gymnema sylvestre leaf extract can reduce serum triglyceride, total cholesterol, very low density lipoprotein-cholesterol and low-density lipoprotein-cholesterol levels in hyperlipidemia rats, and recover Decreased high-density lipoprotein-cholesterol and anti-atherosclerotic index in hyperlipidemic rats.

Inhibition of sweet taste response:

Gymnema sylvestre may inhibit the sweet taste response by blocking the sweet receptors on the surface of taste cells.

Anti-caries effect:

Dental caries is caused by the conversion of glucose into water-insoluble glucan by Streptococcus in the oral cavity, which adheres to the enamel on the tooth surface. Gymnemic acid can significantly inhibit the activity of glucosyltransferase, block the synthesis of extracellular water-insoluble glucan of Streptococcus mutans, inhibit the formation of dental plaque, and make the cariogenic bacteria lose the cariogenic environment, thereby achieving the effect of preventing caries.

Weight loss effect:

Gymnemic acid (GA) has the effect of weight loss because GA can reduce the body's absorption of sugar in addition to reducing the desire for sweets.

Anti-tumor and anti-inflammatory effects:

The primary feature of tumors is the imbalance of malignant proliferation, cell proliferation and apoptosis. Anti-proliferation and pro-apoptosis are effective strategies for the treatment of tumors.

Antioxidant and anti-radiation effects:

The research found that the mechanism of Gymnema sylvestre’s anti-oxidative effect is to exert its anti-oxidative effect by inhibiting DPPH free radicals and scavenging superoxide and hydrogen peroxide groups. The antioxidant active components of Gymnema sylvestre may be related to compounds such as flavonoids, phenols, saponins and triterpenoids in Gymnema sylvestre.

Antibacterial and antiviral effects:

The inhibitory effect of Gymnema sylvestre extract on microorganisms such as bacteria and fungi was studied, and it was found that natural saponins and purified saponins of different concentrations had obvious antibacterial effects.

Immunomodulatory effect:

Gymnema sylvestre water extract shows activity on human neutrophils and has a good immunomodulatory effect.

Other pharmacological effects:

Gymnema sylvestre crude extract can effectively kill the larvae of mosquitoes that can transmit malaria and filariasis. It is a natural insecticide and has no toxic effect on the environment.