Gotu Kola Extract 40% Asiaticosides | 16830-15-2

Introduction of Gotu Kola extract 40% Asiaticosides:

Centella asiatica, the dried whole grass of Centella asiatica, was first recorded in the "Shen Nong's Materia Medica" and listed as a middle grade.

It has the effects of clearing away heat and dampness, detoxifying and reducing swelling. Treatment of bruises, skin diseases, etc.

The main active ingredients in Centella asiatica extract that can be used in cosmetics are asiatic acid, madecassic acid, madecassoside and madecassoside, madecassoside is a triterpenoid saponin of Centella asiatica It is one of the active ingredients with the highest proportion, accounting for about 30% of the total glycosides of Centella asiatica.

The efficacy and role of Gotu Kola extract 40% Asiaticosides： 

Antibacterial

Centella asiatica extract contains asiatic acid and madecassolic acid, these active saponins will acidify the cytoplasm in plant cells, this antibacterial activity can protect the plant itself against mold and yeast attack, experiments show that Centella asiatica

The extract has a certain inhibitory effect on Pseudomonas aeruginosa, Staphylococcus aureus and Propionibacterium acnes.

Anti-inflammatory

Centella asiatica total glycosides have obvious anti-inflammatory effects: reduce the production of pro-inflammatory mediators (L-1, MMP-1), improve and repair the skin's own barrier function, thereby preventing and correcting skin immune dysfunction.

Healing wounds and scars

Madecassoside and madecassoside are the active ingredients of Centella asiatica in the treatment of burn healing wounds.

They can promote collagen synthesis and angiogenesis in the body, stimulate granulation growth and other important roles, so they are beneficial to wound healing.

At the same time, asiaticoside has a proliferation effect on epidermal keratinocytes and vascular endothelial cells, and has an inhibitory effect on fibroblasts, thereby promoting the formation of granulation tissue in the early stage of wound healing, and inhibiting scar formation in the late stage of wound healing effect.

Anti-aging

Centella asiatica extract can promote the synthesis of collagen I and III, as well as the secretion of mucopolysaccharides (such as the synthesis of sodium hyaluronate), increase the skin's water retention, activate and renew skin cells, soothe, enhance and improve the skin. Glossy.

On the other hand, the DNA sequence test found that Centella asiatica extract also activates fibroblast genes, which can enhance the vitality of skin basal cells, maintain skin elasticity and firmness, and smooth fine facial wrinkles.

Antioxidant

Asiaticoside, madecassoic acid and madecassoic acid all have obvious antioxidant activities.

The results of animal experiments show that madecassoside can induce local superoxide dismutase, glutathione and peroxidase in wounds in the early stage of wound healing.

The levels of antioxidants such as catalase, VitChing, VitE were significantly increased, and the level of lipid peroxides in the wound was reduced by 7 times.

Whitening

Asiaticoside can inhibit tyrosinase activity in a dose-dependent manner, and 4μg/ml asiaticoside inhibits tyrosinase by 4%.