Apple Root Extract 80% Phloridzin | 85251-63-4

Product Description:

Apple root bark extract, real name phloretin, foreign name Dihydronaringenin, phloretin chemical name: 3-(4-hydroxyphenyl)-1-(2, 4, 6-trihydroxyphenyl)-1-propanone. 

Phloretin is a new type of natural skin whitening agent recently researched and developed abroad. It is mainly distributed in the peel and root bark of juicy fruits such as apples and pears.

The efficacy and role of Apple Root Extract 80% Phloridzin： 

Antioxidant, anti free radical effect Studies have shown that phloretin can inhibit the activity of melanocytes and has a lightening effect on various skin pigmentation.

1）It has a good inhibitory effect on tyrosinase, and is a very safe and effective freckle whitening agent.

2）Phloretin has a very good moisturizing effect and can absorb 4-5 times its own weight in water.

3) Phloretin is a very safe and effective transdermal penetration enhancer, which can promote the absorption and utilization of other functional factors in the formula, so that it can exert a better effect.

4) Phloretin has a good LOX inhibitory effect, therefore, phloretin is also a good anti-hair loss agent.

Anti-inflammatory and immunosuppressive effects Studies have shown that the occurrence of inflammation is related to NO, which is catalyzed and synthesized by NO synthase, and excessive NO in pathological conditions is catalyzed by inducible NO synthase.

Under the action of phloretin, the NO release of macrophages under the stimulation of lipopolysaccharide and IFN-γ was significantly decreased; the phagocytosis rate of megalith cells was also significantly decreased under the action of phloretin.

Therefore, phloretin has potential anti-inflammatory effects. In immunosuppression, phloretin is a known competitive inhibitor of the sodium D-glucose cotransporter. Since it can increase the fluidity of lipid bilayers in cells, it can play a role in increasing the type and activity of drugs delivered across the membrane through the skin.

Anti-tumor and anti-cancer effects γδT cells are innate immune T cells that widely exist in mucosal and epithelial tissues of the digestive system, respiratory system, etc.

Its anti-tumor effect, in addition to some functional characteristics similar to αβT cells, also recognizes antigens without MHC molecule presentation. , Direct recognition of protein and peptide antigens, non-peptide antigens, with the function of antigen extraction and immune regulation through cell contact and secretion of cytokines.